Projects

Extracellular vesicles -cell and -ECM dynamics: mechanisms in health and disease

Mesenchymal Stem Cells -extracellular vesicles in neuronal cell survival

The focus of this project is on tracking neuroprotection of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and their cargo. Through a multi-omics approach, we have identified MSC-EV-specific cargo (proteins, cytokines and miRNA) that are enriched in MSC-EVs and could potentially be used as neuroprotective agents against neurological conditions such as Alzheimer's disease.

Induced pluripotent stem cell models of human brain

Extracellular transglutaminase-2 in tissue fibrosis: a new therapeutic avenue

What is Transglutaminase-2? Transglutaminase type 2 (TG2) (EC 2.3.2.13), which belongs to an emergent class of proteins with distinct molecular activities, functions both inside and outside the cell and transits the plasma membrane by unconventional secretion.

3D transcriptomics to understand fibrosis progression

Urinary extracellular vesicles proteomics/transcriptomics and markers of CKD progression